Postdoc in theory of evolution: modeling the evolution of self-incompatibility.The Friedlander lab studies theoretically how biological networks evolve. Most evolutionary models consider the evolution of a single gene, regardless of its network context. Genes, however, are often part of a network, where the products of one gene affect the activity of others.
A fascinating example for a medium-sized network of interacting molecules is the self-incompatibility system of plants. This system enables plants to distinguish between self and non-self fertilization by specific matches and mismatches between pairs of specialized proteins. This immediately raises fundamental theoretical questions about the evolutionary emergence and maintenance of this mechanism. The exact project will be tailored with the candidate.
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