CRISPR-Cas is a prokaryotic adaptive immune system with exciting applications in genome engineering. The CRISPR-Cas system is far more complex than just Cas9, and many fundamental questions about its mechanism remain unresolved. We are focused on type III CRISPR systems that operate by detecting foreign RNA and generating a cyclic nucleotide second messenger. We wish to recruit a research fellow to study the molecular biology of the CRISPR system and in particular focus on the mechanism by which cyclic nucleotides are sensed as a signal of viral infection by effector proteins. The successful applicant will have a PhD degree in the Life Sciences and experience in the areas of biochemistry, molecular biology and molecular microbiology. Experience in the areas of protein:nucleic acid interactions or phage:host interactions would be advantageous.
The post, which is available from 1st April 2020 for up to 2 years, is funded by the BBSRC. This project is based in the laboratory of Professor Malcolm White in the Biomedical Sciences Research Complex (BSRC) at the University of St Andrews. You will join a well-funded, enthusiastic and friendly group working on aspects of the CRISPR system.
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